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KMID : 1234420090370010080
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Korean Journal of Microbiololgy and Biotechnology
2009 Volume.37 No. 1 p.80 ~ p.84
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Antimicrobial Activities of the Anti-acne Compounds from Natural Sources
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Kim Na-Rae
Lim Young-Hee
Park Sul-Woong
Nam Eun-Sil
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Abstract
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The in vitro antibacterial activities of anti-acne agents prepared from the extracts of natural sources were investigated against several bacteria including antibiotic-susceptible and -resistant Propionibacterium acnes. SD-1 and SD-2 were prepared with different formulations and they showed strong antibacterial activities. The anti-acne agents completely inhibited the growth of the tested strains at the concentration of 0.5%. There was no difference in antibacterial activity between antibiotic-susceptible and -resistant P. acnes. The inhibitory activities of two agents showed time-dependent manner. In S. aureus, time-kill curve demonstrated 2.8- and 3.4-log10-unit killing after 8 h with SD-1 and SD-2, respectively. In P. acnes, time-killing curve demonstrated 5.1- and 6.1-log10-unit killing after 24 h with SD-1 and SD-2, respectively. SD-2 showed stronger antimicrobial activity than SD-1. From these results, we expect that SD-1 and SD-2 have strong antibacterial activities and have advantages for treating acne.
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KEYWORD
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Anti-acne, Propionibacterium acnes, antimicrobial activity
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